PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

OBJECTIVE(S): Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore,...

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Veröffentlicht in:Iran J Basic Med Sci
Hauptverfasser: Komeili-Movahhed, Tahereh, Fouladdel, Shamileh, Barzegar, Elmira, Atashpour, Shekoufeh, Hossein Ghahremani, Mohammad, Nasser Ostad, Seyed, Madjd, Zahra, Azizi, Ebrahim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mashhad University of Medical Sciences 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475655/
https://ncbi.nlm.nih.gov/pubmed/26124933
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