PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

OBJECTIVE(S): Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore,...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Iran J Basic Med Sci
Main Authors: Komeili-Movahhed, Tahereh, Fouladdel, Shamileh, Barzegar, Elmira, Atashpour, Shekoufeh, Hossein Ghahremani, Mohammad, Nasser Ostad, Seyed, Madjd, Zahra, Azizi, Ebrahim
פורמט: Artigo
שפה:Inglês
יצא לאור: Mashhad University of Medical Sciences 2015
נושאים:
Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475655/
https://ncbi.nlm.nih.gov/pubmed/26124933
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