Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll Like Receptor 9

BACKGROUND AND AIMS: The mechanisms of hypoxia-induced tumor growth remain unclear. Hypoxia induces intracellular translocation and release of a variety of damage associated molecular patterns (DAMPs) such as nuclear HMGB1 and mitochondrial DNA (mtDNA). In inflammation, Toll-like receptor (TLR)-9 ac...

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Bibliografiset tiedot
Julkaisussa:J Hepatol
Päätekijät: Liu, Yao, Yan, Wei, Tohme, Samer, Chen, Man, Fu, Yu, Tian, Dean, Lotze, Michael, Tang, Daolin, Tsung, Allan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475488/
https://ncbi.nlm.nih.gov/pubmed/25681553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.02.009
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