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RNA degradation drives stem cell differentiation

The mechanisms by which multi-potent stem cells switch their program to become functional differentiated cells have intrigued biologists for decades. Most focus has been on transcriptional pathways, but whether they have sufficient dynamic range to cause discrete shifts in cell state is not clear. B...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Lou, Chih-Hong, Shum, Eleen Y, Wilkinson, Miles F
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475395/
https://ncbi.nlm.nih.gov/pubmed/25899816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591631
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