Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate

Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to be expressed at higher levels in human pluripotent cells...

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Udgivet i:Stem Cell Reports
Main Authors: Lou, Chih-Hong, Dumdie, Jennifer, Goetz, Alexandra, Shum, Eleen Y., Brafman, David, Liao, Xiaoyan, Mora-Castilla, Sergio, Ramaiah, Madhuvanthi, Cook-Andersen, Heidi, Laurent, Louise, Wilkinson, Miles F.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912386/
https://ncbi.nlm.nih.gov/pubmed/27304915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.05.008
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