FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

Most cartilaginous tumors are formed during skeletal development in locations adjacent to growth plates, suggesting that they arise from disordered endochondral bone growth. Fibroblast growth factor receptor (FGFR)3 signaling plays essential roles in this process; however, the role of FGFR3 in carti...

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Vydáno v:PLoS Genet
Hlavní autoři: Zhou, Siru, Xie, Yangli, Tang, Junzhou, Huang, Junlan, Huang, Qizhao, Xu, Wei, Wang, Zuqiang, Luo, Fengtao, Wang, Quan, Chen, Hangang, Du, Xiaolan, Shen, Yue, Chen, Di, Chen, Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474636/
https://ncbi.nlm.nih.gov/pubmed/26091072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005214
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