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Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling
We modeled cellular epidermal growth factor receptor (EGFR) tyrosine phosphorylation dynamics in the presence of receptor-targeting kinase inhibitors (e.g., gefitinib) or antibodies (e.g., cetuximab) to identify systematically the factors that contribute most to the ability of the therapeutics to an...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4474171/ https://ncbi.nlm.nih.gov/pubmed/25317724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.39 |
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