Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines

BACKGROUND: Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augmented hemodynamic support (HS) and improved survival with lethal toxin challenge....

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Veröffentlicht in:Intensive Care Med Exp
Hauptverfasser: Remy, Kenneth E, Cui, Xizhong, Li, Yan, Sun, Junfeng, Solomon, Steven B, Fitz, Yvonne, Barochia, Amisha V, Al-Hamad, Mariam, Moayeri, Mahtab, Leppla, Stephen H, Eichacker, Peter Q
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473792/
https://ncbi.nlm.nih.gov/pubmed/26097803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-015-0043-4
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