Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

Salmonella PhoQ is a histidine kinase with a periplasmic sensor domain (PD) that promotes virulence by detecting the macrophage phagosome. PhoQ activity is repressed by divalent cations and induced in environments of acidic pH, limited divalent cations, and cationic antimicrobial peptides (CAMP). Pr...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Hicks, Kevin G, Delbecq, Scott P, Sancho-Vaello, Enea, Blanc, Marie-Pierre, Dove, Katja K, Prost, Lynne R, Daley, Margaret E, Zeth, Kornelius, Klevit, Rachel E, Miller, Samuel I
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Biochemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473727/
https://ncbi.nlm.nih.gov/pubmed/26002083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06792
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