Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration

High-throughput integration site (IS) analysis of wild-type adeno-associated virus type 2 (wtAAV2) in human dermal fibroblasts (HDFs) and HeLa cells revealed that juxtaposition of a Rep binding site (RBS) and terminal resolution site (trs)-like motif leads to a 4-fold-increased probability of wtAAV...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Petri, Karl, Gabriel, Richard, Agundez, Leticia, Fronza, Raffaele, Afzal, Saira, Kaeppel, Christine, Linden, R. Michael, Henckaerts, Els, Schmidt, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473589/
https://ncbi.nlm.nih.gov/pubmed/25972561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00426-15
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