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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

Germ-line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a high likelihood of developing colorectal carcinomas. To understand...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Fodde, R, Edelmann, W, Yang, K, van Leeuwen, C, Carlson, C, Renault, B, Breukel, C, Alt, E, Lipkin, M, Khan, P M
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44728/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8090754/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.8969
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