A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

Germ-line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a high likelihood of developing colorectal carcinomas. To understand...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Fodde, R, Edelmann, W, Yang, K, van Leeuwen, C, Carlson, C, Renault, B, Breukel, C, Alt, E, Lipkin, M, Khan, P M
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44728/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8090754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.8969
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