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Non-toxic antimicrobials that evade drug resistance

Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. But this benefit often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded resistance for more than half a cen...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Davis, Stephen A., Vincent, Benjamin M., Endo, Matthew M., Whitesell, Luke, Marchillo, Karen, Andes, David R., Lindquist, Susan, Burke, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472574/
https://ncbi.nlm.nih.gov/pubmed/26030729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1821
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