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Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

The evolution of drug resistance in microbial pathogens provides a paradigm for investigating evolutionary dynamics with important consequences for human health. Candida albicans, the leading fungal pathogen of humans, rapidly evolves resistance to two major antifungal classes, the triazoles and ech...

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Hlavní autoři: Vincent, Benjamin Matteson, Lancaster, Alex Kelvin, Scherz-Shouval, Ruth, Whitesell, Luke, Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812114/
https://ncbi.nlm.nih.gov/pubmed/24204207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001692
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