ASXL2 regulates glucose, lipid and skeletal homeostasis

ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2−/− mice are insulin resistant, lipodystrophic and fail to respond to a high fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2−/− mice are also severely osteopetrotic due to...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Izawa, Takashi, Rohatgi, Nidhi, Fukunaga, Tomohiro, Wang, Qun-Tian, Silva, Matthew J., Gardner, Michael J., McDaniel, Michael L., Abumrad, Nada A., Semenkovich, Clay F., Teitelbaum, Steven L., Zou, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472564/
https://ncbi.nlm.nih.gov/pubmed/26051940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.019
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