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Repolarization Reserve Evolves Dynamically During the Cardiac Action Potential: Effects of Transient Outward Currents on Early Afterdepolarizations

BACKGROUND: Transient outward K currents (I(to)) have been reported both to suppress and facilitate early afterdepolarizations (EADs) when repolarization reserve is reduced. Here we used the dynamic clamp technique to analyze how I(to) accounts for these paradoxical effects on EADs by influencing th...

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Bibliografische gegevens
Gepubliceerd in:Circ Arrhythm Electrophysiol
Hoofdauteurs: Nguyen, Thao P., Singh, Neha, Xie, Yuanfang, Qu, Zhilin, Weiss, James N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472560/
https://ncbi.nlm.nih.gov/pubmed/25772542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.114.002451
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