α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer’s disease, it is critical to determine whether α7β2 nAChRs are present in the huma...

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Udgivet i:PLoS One
Main Authors: Thomsen, Morten Skøtt, Zwart, Ruud, Ursu, Daniel, Jensen, Majbrit Myrup, Pinborg, Lars Hageman, Gilmour, Gary, Wu, Jie, Sher, Emanuele, Mikkelsen, Jens Damsgaard
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472343/
https://ncbi.nlm.nih.gov/pubmed/26086615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130572
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