Structural differences of amyloid-β fibrils revealed by antibodies from phage display

BACKGROUND: Beside neurofibrillary tangles, amyloid plaques are the major histological hallmarks of Alzheimer’s disease (AD) being composed of aggregated fibrils of β-amyloid (Aβ). During the underlying fibrillogenic pathway, starting from a surplus of soluble Aβ and leading to mature fibrils, multi...

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Publicat a:BMC Biotechnol
Autors principals: Droste, Patrick, Frenzel, André, Steinwand, Miriam, Pelat, Thibaut, Thullier, Philippe, Hust, Michael, Lashuel, Hilal, Dübel, Stefan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472244/
https://ncbi.nlm.nih.gov/pubmed/26084577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0146-8
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