Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced Conversion (RT-QuIC) would facilitate prion disease diagnosis, surveillance and research. Previous studies have shown that...

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Pubblicato in:PLoS Pathog
Autori principali: Orrú, Christina D., Groveman, Bradley R., Raymond, Lynne D., Hughson, Andrew G., Nonno, Romolo, Zou, Wenquan, Ghetti, Bernardino, Gambetti, Pierluigi, Caughey, Byron
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472236/
https://ncbi.nlm.nih.gov/pubmed/26086786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004983
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