Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes

Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bone Res
Hauptverfasser: Zhang, Fengjie, He, Qiling, Tsang, Wing Pui, Garvey, W Timothy, Chan, Wai Yee, Wan, Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472128/
https://ncbi.nlm.nih.gov/pubmed/26273523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2014.12
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