Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson’s disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown....

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Pubblicato in:Stem Cell Reports
Autori principali: Grealish, Shane, Heuer, Andreas, Cardoso, Tiago, Kirkeby, Agnete, Jönsson, Marie, Johansson, Jenny, Björklund, Anders, Jakobsson, Johan, Parmar, Malin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471831/
https://ncbi.nlm.nih.gov/pubmed/26004633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.04.011
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