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Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane

BACKGROUND: The mechanisms by which volatile anaesthetics such as isoflurane alter neuronal function are poorly understood, in particular their presynaptic mechanisms. Presynaptic voltage-gated sodium channels (Na(v)) have been implicated as a target for anaesthetic inhibition of neurotransmitter re...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Purtell, K., Gingrich, K. J., Ouyang, W., Herold, K. F., Hemmings, H. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471819/
https://ncbi.nlm.nih.gov/pubmed/26089447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bja/aev203
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