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Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane
Volatile anesthetics depress neurotransmitter release in a brain region- and neurotransmitter-selective manner by unclear mechanisms. Voltage-gated sodium channels (Na(v)s), which are coupled to synaptic vesicle exocytosis, are inhibited by volatile anesthetics through reduction of peak current and...
Uloženo v:
| Vydáno v: | J Pharmacol Exp Ther |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6439525/ https://ncbi.nlm.nih.gov/pubmed/30792243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254938 |
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