Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role in both bone homeostasis and inflammatory dis...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Kang, Heeseog, Kerloc’h, Audrey, Rotival, Maxime, Xu, Xiaoqing, Zhang, Qing, D’Souza, Zelpha, Kim, Michael, Scholz, Jodi Carlson, Ko, Jeong-Hun, Srivastava, Prashant K., Genzen, Jonathan R., Cui, Weiguo, Aitman, Timothy J., Game, Laurence, Melvin, James E., Hanidu, Adedayo, Dimock, Janice, Zheng, Jie, Souza, Donald, Behera, Aruna K., Nabozny, Gerald, Cook, H. Terence, Bassett, J.H. Duncan, Williams, Graham R., Li, Jun, Vignery, Agnès, Petretto, Enrico, Behmoaras, Jacques
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471813/
https://ncbi.nlm.nih.gov/pubmed/25131209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.032
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