Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat macrophages to unravel their genetic determinants of multinucleation and investigate their role in both bone homeostasis and inflammatory dis...

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Published in:Cell Rep
Main Authors: Kang, Heeseog, Kerloc’h, Audrey, Rotival, Maxime, Xu, Xiaoqing, Zhang, Qing, D’Souza, Zelpha, Kim, Michael, Scholz, Jodi Carlson, Ko, Jeong-Hun, Srivastava, Prashant K., Genzen, Jonathan R., Cui, Weiguo, Aitman, Timothy J., Game, Laurence, Melvin, James E., Hanidu, Adedayo, Dimock, Janice, Zheng, Jie, Souza, Donald, Behera, Aruna K., Nabozny, Gerald, Cook, H. Terence, Bassett, J.H. Duncan, Williams, Graham R., Li, Jun, Vignery, Agnès, Petretto, Enrico, Behmoaras, Jacques
Format: Artigo
Language:Inglês
Published: Cell Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471813/
https://ncbi.nlm.nih.gov/pubmed/25131209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.032
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