Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

BACKGROUND: The oxidative burst is one of the major antimicrobial mechanisms adopted by macrophages. The WKY rat strain is uniquely susceptible to experimentally induced macrophage-dependent crescentic glomerulonephritis (Crgn). We previously identified the AP-1 transcription factor JunD as a determ...

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Autors principals: Hull, Richard P, Srivastava, Prashant K, D’Souza, Zelpha, Atanur, Santosh S, Mechta-Grigoriou, Fatima, Game, Laurence, Petretto, Enrico, Cook, H Terence, Aitman, Timothy J, Behmoaras, Jacques
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608227/
https://ncbi.nlm.nih.gov/pubmed/23398888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-92
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