A trans-eQTL network regulates osteoclast multinucleation and bone mass

Functional characterisation of cell-type-specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes to in vivo phenotype as its multinucleation and resorption ac...

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Pubblicato in:eLife
Autori principali: Pereira, Marie, Ko, Jeong-Hun, Logan, John, Protheroe, Hayley, Kim, Kee-Beom, Tan, Amelia Li Min, Croucher, Peter I, Park, Kwon-Sik, Rotival, Maxime, Petretto, Enrico, Bassett, JH Duncan, Williams, Graham R, Behmoaras, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351491/
https://ncbi.nlm.nih.gov/pubmed/32553114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55549
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