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Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**
Elaiophylin is an unusual C(2)-symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. To probe the mechanism and selectivity of diolide formation, we sought to reconstitute ring formation in vitro by using a non-natural substrate. Incubation of recombina...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
WILEY-VCH Verlag
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4471547/ https://ncbi.nlm.nih.gov/pubmed/25753953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201500401 |
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