Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Paul, Manoj, Hemshekhar, Mahadevappa, Thushara, Ram M., Sundaram, Mahalingam S., NaveenKumar, Somanathapura K., Naveen, Shivanna, Devaraja, Sannaningaiah, Somyajit, Kumar, West, Robert, Basappa, Nayaka, Siddaiah C., Zakai, Uzma I., Nagaraju, Ganesh, Rangappa, Kanchugarakoppal S., Kemparaju, Kempaiah, Girish, Kesturu S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471342/
https://ncbi.nlm.nih.gov/pubmed/26083398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127558
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak