Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Paul, Manoj, Hemshekhar, Mahadevappa, Thushara, Ram M., Sundaram, Mahalingam S., NaveenKumar, Somanathapura K., Naveen, Shivanna, Devaraja, Sannaningaiah, Somyajit, Kumar, West, Robert, Basappa, Nayaka, Siddaiah C., Zakai, Uzma I., Nagaraju, Ganesh, Rangappa, Kanchugarakoppal S., Kemparaju, Kempaiah, Girish, Kesturu S.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471342/
https://ncbi.nlm.nih.gov/pubmed/26083398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127558
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