Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Paul, Manoj, Hemshekhar, Mahadevappa, Thushara, Ram M., Sundaram, Mahalingam S., NaveenKumar, Somanathapura K., Naveen, Shivanna, Devaraja, Sannaningaiah, Somyajit, Kumar, West, Robert, Basappa, Nayaka, Siddaiah C., Zakai, Uzma I., Nagaraju, Ganesh, Rangappa, Kanchugarakoppal S., Kemparaju, Kempaiah, Girish, Kesturu S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471342/
https://ncbi.nlm.nih.gov/pubmed/26083398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127558
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