The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellul...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Bunney, Tom D., Wan, Shunzhou, Thiyagarajan, Nethaji, Sutto, Ludovico, Williams, Sarah V., Ashford, Paul, Koss, Hans, Knowles, Margaret A., Gervasio, Francesco L., Coveney, Peter V., Katan, Matilda
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471147/
https://ncbi.nlm.nih.gov/pubmed/26097890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.02.009
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