SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

SerpinB2 (PAI-2), a member of the clade B family of serine protease inhibitors, is one of the most upregulated proteins following cellular stress. Originally described as an inhibitor of urokinase plasminogen activator, its predominant cytoplasmic localisation suggests an intracellular function. Ser...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Jodi A., Yerbury, Justin J., Farrawell, Natalie, Shearer, Robert F., Constantinescu, Patrick, Hatters, Danny M., Schroder, Wayne A., Suhrbier, Andreas, Wilson, Mark R., Saunders, Darren N., Ranson, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470917/
https://ncbi.nlm.nih.gov/pubmed/26083412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130136
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