Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384

PURPOSE: Radiation remains a mainstay for the treatment of non-metastatic head and neck squamous cell carcinoma (HNSCC), a malignancy characterized by a high rate of PI3K/mTOR signaling axis activation. We investigated the ATP-competitive dual PI3K/mTOR inhibitor, PF-05212384, as a radiosensitizer i...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Leiker, Andrew J., DeGraff, William, Choudhuri, Rajani, Sowers, Anastasia L., Thetford, Angela, Cook, John A., Van Waes, Carter, Mitchell, James B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470749/
https://ncbi.nlm.nih.gov/pubmed/25724523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3279
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