The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression

Here evidence suggests that nitric oxide synthases (NOS) of tumor cells, in contrast to normal tissues, synthesize predominantly superoxide and peroxynitrite. Based on HPLC analysis, the underlying mechanism for this uncoupling is a reduced tetrahydrobiopterin: dihydrobiopterin ratio (BH4:BH2) found...

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Bibliografische gegevens
Gepubliceerd in:Mol Cancer Res
Hoofdauteurs: Rabender, Christopher S., Alam, Asim, Sundaresan, Gobalakrishnan, Cardnell, Robert J., Yakovlev, Vasily A., Mukhopadhyay, Nitai D., Graves, Paul, Zweit, Jamal, Mikkelsen, Ross B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470720/
https://ncbi.nlm.nih.gov/pubmed/25724429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0057-T
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