The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression

Here evidence suggests that nitric oxide synthases (NOS) of tumor cells, in contrast to normal tissues, synthesize predominantly superoxide and peroxynitrite. Based on HPLC analysis, the underlying mechanism for this uncoupling is a reduced tetrahydrobiopterin: dihydrobiopterin ratio (BH4:BH2) found...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Rabender, Christopher S., Alam, Asim, Sundaresan, Gobalakrishnan, Cardnell, Robert J., Yakovlev, Vasily A., Mukhopadhyay, Nitai D., Graves, Paul, Zweit, Jamal, Mikkelsen, Ross B.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470720/
https://ncbi.nlm.nih.gov/pubmed/25724429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0057-T
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