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Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

Human melanoma cells required ligation of the integrin alpha v beta 3 to sustain viability and growth in three-dimensional dermal collagen. Variant melanoma cells, lacking the alpha v subunit, progressed rapidly to apoptosis within this matrix, whereas transfection of these cells with an alpha v cDN...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Montgomery, A M, Reisfeld, R A, Cheresh, D A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7522323/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.8856
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