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Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery

One major challenge in gene therapy is the host immune responses against viral vectors. Previous studies indicate the involvement of NK cells in stunted gene expression in viral vector mediated gene therapy. To understand the problem of the immune responses, we have developed an in-vitro co-culture...

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Detalhes bibliográficos
Publicado no:Cell Biosci
Main Authors: Ankathatti Munegowda, Manjunatha, Hu, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470062/
https://ncbi.nlm.nih.gov/pubmed/26085921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-015-0023-0
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