Nalaganje...
Enhanced Factor VIIIa Stability of A2 Domain Interface Variants Results from an Increased Affinity for the A2 Subunit
Factor (F)VIIIa, a heterotrimer comprised of A1, A2, and A3C1C2 subunits, is labile due to the tendency of the A2 subunit to dissociate from the A1/A3C1C2 dimer. As dissociation of the A2 subunit inactivates FVIIIa activity, retention of A2 defines FVIIIa stability and thus, FXase activity. Earlier...
Shranjeno v:
| izdano v: | Thromb Haemost |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4469990/ https://ncbi.nlm.nih.gov/pubmed/24899227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH14-01-0086 |
| Oznake: |
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