The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1α Stability and Angiogenesis

Hypoxia-inducible factor (HIF) is a key regulator of tumor growth and angiogenesis. Recent studies have shown that, BIX01294, a G9a histone methyltransferase (HMT)-specific inhibitor, induces apoptosis and inhibits the proliferation, migration, and invasion of cancer cells. However, not many studies...

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Опубликовано в: :Mol Cells
Главные авторы: Oh, Su Young, Seok, Ji Yoon, Choi, Young Sun, Lee, Sung Hee, Bae, Jong-Sup, Lee, You Mie
Формат: Artigo
Язык:Inglês
Опубликовано: Korean Society for Molecular and Cellular Biology 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469910/
https://ncbi.nlm.nih.gov/pubmed/26013382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2015.0026
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