Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

Background: Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of...

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Bibliographic Details
Published in:Int J Epidemiol
Main Authors: Burgess, Stephen, Daniel, Rhian M, Butterworth, Adam S, Thompson, Simon G
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Mendelian Randomization Methodology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469795/
https://ncbi.nlm.nih.gov/pubmed/25150977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyu176
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