N-glycosylation is essential for ileal ASBT function and protection against proteases

The bile acid transporter ASBT is a glycoprotein responsible for active absorption of bile acids. Inhibiting ASBT function and bile acid absorption is an attractive approach to lower plasma cholesterol and improve glucose imbalance in diabetic patients. Deglycosylation of ASBT was shown to decrease...

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Gepubliceerd in:Am J Physiol Cell Physiol
Hoofdauteurs: Muthusamy, Saminathan, Malhotra, Pooja, Hosameddin, Mobashir, Dudeja, Amish K., Borthakur, Sujata, Saksena, Seema, Gill, Ravinder K., Dudeja, Pradeep K., Alrefai, Waddah A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469748/
https://ncbi.nlm.nih.gov/pubmed/25855079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00023.2015
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