N-glycosylation is essential for ileal ASBT function and protection against proteases

The bile acid transporter ASBT is a glycoprotein responsible for active absorption of bile acids. Inhibiting ASBT function and bile acid absorption is an attractive approach to lower plasma cholesterol and improve glucose imbalance in diabetic patients. Deglycosylation of ASBT was shown to decrease...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Muthusamy, Saminathan, Malhotra, Pooja, Hosameddin, Mobashir, Dudeja, Amish K., Borthakur, Sujata, Saksena, Seema, Gill, Ravinder K., Dudeja, Pradeep K., Alrefai, Waddah A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469748/
https://ncbi.nlm.nih.gov/pubmed/25855079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00023.2015
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