N-glycosylation is essential for ileal ASBT function and protection against proteases

The bile acid transporter ASBT is a glycoprotein responsible for active absorption of bile acids. Inhibiting ASBT function and bile acid absorption is an attractive approach to lower plasma cholesterol and improve glucose imbalance in diabetic patients. Deglycosylation of ASBT was shown to decrease...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Muthusamy, Saminathan, Malhotra, Pooja, Hosameddin, Mobashir, Dudeja, Amish K., Borthakur, Sujata, Saksena, Seema, Gill, Ravinder K., Dudeja, Pradeep K., Alrefai, Waddah A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469748/
https://ncbi.nlm.nih.gov/pubmed/25855079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00023.2015
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