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Bottom-up and middle-down proteomics have comparable accuracies in defining histone PTM relative abundance and stoichiometry
Histone proteins are key components of chromatin. Their N-terminal tails are enriched in combinatorial post-translational modifications (PTMs), which influence gene regulation, DNA repair and chromosome condensation. Mass spectrometry (MS)-based middle-down proteomics has emerged as technique to ana...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4469134/ https://ncbi.nlm.nih.gov/pubmed/25719549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b00072 |
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