Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

We report a new series of 8-membered benzo-fused lactams that inhibit cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI). The series was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repos...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Dockendorff, Chris, Faloon, Patrick W., Pu, Jun, Yu, Miao, Johnston, Stephen, Bennion, Melissa, Penman, Marsha, Nieland, Thomas J. F., Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469080/
https://ncbi.nlm.nih.gov/pubmed/25900219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.073
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