Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repository (NIH MLSMR)...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Yu, Miao, Youngsaye, Willmen, Nag, Partha P., Bennion, Melissa, Penman, Marsha, Nieland, Thomas J. F., Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469081/
https://ncbi.nlm.nih.gov/pubmed/25958245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.074
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