A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas

BACKGROUND: In previous years, immunotoxins have been shown to be a greatly promising therapeutic tool for brain malignancies, such as gliomas. Human mesenchymal stem cells (hMSCs) exhibit tropism to tumor tissue. However, the effect of bispecific immunotoxins in malignant gliomas is still unknown....

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Zhang, Yonghong, Sun, Xinlin, Huang, Min, Ke, Yiquan, Wang, Jihui, Liu, Xiao
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468939/
https://ncbi.nlm.nih.gov/pubmed/26089644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S79475
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