Histone Deacetylase Inhibitor Romidepsin Inhibits De Novo HIV-1 Infections

Adjunct therapy with the histone deacetylase inhibitor (HDACi) romidepsin increases plasma viremia in HIV patients on combination antiretroviral therapy (cART). However, a potential concern is that reversing HIV latency with an HDACi may reactivate the virus in anatomical compartments with suboptima...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Jønsson, Kasper L., Tolstrup, Martin, Vad-Nielsen, Johan, Kjær, Kathrine, Laustsen, Anders, Andersen, Morten N., Rasmussen, Thomas A., Søgaard, Ole S., Østergaard, Lars, Denton, Paul W., Jakobsen, Martin R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468708/
https://ncbi.nlm.nih.gov/pubmed/25896701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00574-15
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