Stability of the Antimalarial Drug Dihydroartemisinin under Physiologically Relevant Conditions: Implications for Clinical Treatment and Pharmacokinetic and In Vitro Assays

Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of condit...

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Bibliographic Details
Published in:	Antimicrob Agents Chemother
Main Authors:	Parapini, Silvia, Olliaro, Piero, Navaratnam, Visweswaran, Taramelli, Donatella, Basilico, Nicoletta
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2015
Subjects:	Pharmacology
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4468699/ https://ncbi.nlm.nih.gov/pubmed/25918150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00183-15
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Stability of the Antimalarial Drug Dihydroartemisinin under Physiologically Relevant Conditions: Implications for Clinical Treatment and Pharmacokinetic and In Vitro Assays

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