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Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we assessed the effects of attaching sugars to N-4 o...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Wu, Yuet, Parapini, Silvia, Williams, Ian D., Misiano, Paola, Wong, Ho Ning, Taramelli, Donatella, Basilico, Nicoletta, Haynes, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100044/
https://ncbi.nlm.nih.gov/pubmed/30011856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071713
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